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Mitochondria in innate immunityMitochondria in innate immunitytextjournalArticleArnoultD.autSoaresF.autTattoliI.autGirardinS. E.authttp://www.ncbi.nlm.nih.gov/pubmed/21799518Mitochondria are cellular organelles involved in host-cell metabolic processes and the control of programmed cell death. A direct link between mitochondria and innate immune signalling was first highlighted with the identification of MAVS-a crucial adaptor for RIGI-like receptor signalling-as a mitochondria-anchored protein. Recently, other innate immune molecules, such as NLRX1, TRAF6, NLRP3 and IRGM have been functionally associated with mitochondria. Furthermore, mitochondrial alarmins-such as mitochondrial DNA and formyl peptides-can be released by damaged mitochondria and trigger inflammation. Therefore, mitochondria emerge as a fundamental hub for innate immune signalling.Adaptor ProteinsInnate Mitochondria/genetics/*immunology/*metabolism Mitochondrial Proteins/genetics/immunology/metabolism Signal Transduction/*immunologySignal Transducing/immunology/metabolism Animals Apoptosis Humans *Immunityjournal12990110September 2011continuing1469-3178 (ELECTRONIC) 1469-221X (LINKING)EMBO Rep