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@article{deschaseaux_hla-g_2011, title = {{HLA}-{G} in organ transplantation: towards clinical applications}, volume = {68}, issn = {1420-9071 (ELECTRONIC) 1420-682X (LINKING)}, shorttitle = {{HLA}-{G} in organ transplantation: towards clinical applications}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21103908}, abstract = {HLA-G plays a particular role during pregnancy in which its expression at the feto-maternal barrier participates into the tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic tool in organ transplantation.}, number = {3}, journal = {Cell Mol Life Sci}, author = {Deschaseaux, F. and Delgado, D. and Pistoia, V. and Giuliani, M. and Morandi, F. and Durrbach, A.}, month = feb, year = {2011}, keywords = {Antigens, Antigens/genetics/*immunology/*therapeutic, Class, Expression, Gene, HLA, HLA-G, Histocompatibility, Humans, I/genetics/*immunology/*therapeutic, Organ, Regulation, Transplantation, use}, pages = {397--404}, }